UR-1505
| Code | Size | Price |
|---|
| TAR-T29072-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T29072-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T29072-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
UR-1505 is a nuclear factor of activated T cells (NF-AT) inhibitor. UR-1505 acts by inhibiting T cell activation depending on T cell receptor signaling pathway. Furthermore, the antiproliferative effects of UR-1505 are not a consequence of decreased cell viability.
CAS:
651331-92-9
Formula:
C10H7F5O4
Molecular Weight:
286.154
Purity:
0.98
SMILES:
OC(=O)c1ccc(OCC(F)(F)C(F)(F)F)cc1O
References
1. Vives R, Pontes C, Sarasa M, Millier A. Safety and Activity of UR-1505 in Atopic Dermatitis: A Randomized, Double-blind Phase II Exploratory Trial. Clin Ther. 2015 Sep 1;37(9):1955-65. doi: 10.1016/j.clinthera.2015.06.005. PubMed PMID: 26163200.
2. Rom?n J, de Arriba AF, Barr?n S, Michelena P, Giral M, Merlos M, Bail?n E, Comalada M, G?lvez J, Zarzuelo A, Ramis I. UR-1505, a new salicylate, blocks T cell activation through nuclear factor of activated T cells. Mol Pharmacol. 2007 Aug;72(2):269-79. PubMed PMID: 17475810.
3. Bail?n E, Rom?n J, Ramis I, Michelena P, Balsa D, Merlos M, Zarzuelo A, G?lvez J, Comalada M. The new salicylate derivative UR-1505 modulates the Th2/humoral response in a dextran sodium sulphate model of colitis that resembles ulcerative colitis. J Pharmacol Sci. 2009 Feb;109(2):315-8. PubMed PMID: 19234369.
4. Bail?n E, Comalada M, Rom?n J, Michelena P, Ramis I, Merlos M, Nieto A, Concha A, Zarzuelo A, G?lvez J. UR-1505, a salicylate able to selectively block T-cell activation, shows intestinal anti-inflammatory activity in the chronic phase of the DSS model of rat colitis. Inflamm Bowel Dis. 2008 Jul;14(7):888-97. doi: 10.1002/ibd.20381. PubMed PMID: 18253952.