V-11-0711
| Code | Size | Price |
|---|
| TAR-T29083-5mg | 5mg | £1,167.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
V-11-0711 is an inhibitor of Chk-α, which may be essential in cancer cell proliferation.
CAS:
1428339-47-2
Formula:
C27H35NO3
Molecular Weight:
421.581
Purity:
0.98
SMILES:
O[C@@](CCc1ccccc1OC1CCOCC1)(C1CN2CC[C@H]1CC2)c1ccccc1
References
1. Koch K, Hartmann R, Schr?ter F, Suwala AK, Maciaczyk D, Kr?ger AC, Willbold D, Kahlert UD, Maciaczyk J. Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells. Oncotarget. 2016 Nov 8;7(45):73414-73431. doi: 10.18632/oncotarget.12337. PubMed PMID: 27705917; PubMed Central PMCID: PMC5341988.
2. Mori N, Wildes F, Kakkad S, Jacob D, Solaiyappan M, Glunde K, Bhujwalla ZM. Choline kinase-? protein and phosphatidylcholine but not phosphocholine are required for breast cancer cell survival. NMR Biomed. 2015 Dec;28(12):1697-706. doi: 10.1002/nbm.3429. Epub 2015 Oct 27. PubMed PMID: 26503172.
3. Falcon SC, Hudson CS, Huang Y, Mortimore M, Golec JM, Charlton PA, Weber P, Sundaram H. A non-catalytic role of choline kinase alpha is important in promoting cancer cell survival. Oncogenesis. 2013;2:e38. PubMed PMID: 25522435; PubMed Central PMCID: PMC3641355.