Verticillin A
| Code | Size | Price |
|---|
| TAR-T29104-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Verticillin A, an apoptosis inducer, inhibits Leiomyosarcoma and Malignant peripheral nerve sheath tumor growth.
CAS:
889640-30-6
Formula:
C30H28N6O6S4
Molecular Weight:
696.83
Purity:
0.98
SMILES:
[H][C@]12C([C@H](O)[C@]34SS[C@](C)(N(C)C3=O)C(=O)N14)c1ccccc1N2c1cccc2N[C@]3([H])N4C(=O)[C@]5(C)SS[C@@]4(C(O)[C@@]3([H])c12)C(=O)N5C
References
1. Wang J, Zhu X, Kolli S, Wang H, Pearce CJ, Oberlies NH, Phelps MA. Plasma pharmacokinetics and bioavailability of verticillin A following different routes of administration in mice using liquid chromatography tandem mass spectrometry. J Pharm Biomed Anal. 2017 May 30;139:187-192. doi: 10.1016/j.jpba.2017.02.051. Epub 2017 Mar 1. PubMed PMID: 28284083; PubMed Central PMCID: PMC5399420.
2. Zewdu A, Lopez G, Braggio D, Kenny C, Constantino D, Bid HK, Batte K, Iwenofu OH, Oberlies NH, Pearce CJ, Strohecker AM, Lev D, Pollock RE. Verticillin A Inhibits Leiomyosarcoma and Malignant Peripheral Nerve Sheath Tumor Growth via Induction of Apoptosis. Clin Exp Pharmacol. 2016 Nov;6(6). pii: 221. doi: 10.4172/2161-1459.1000221. Epub 2016 Oct 24. PubMed PMID: 28184331; PubMed Central PMCID: PMC5295762.
3. Paschall AV, Liu K. Epigenetic Regulation of Apoptosis and Cell Cycle Regulatory Genes in Human Colon Carcinoma Cells. Genom Data. 2015 Sep 1;5:189-191. PubMed PMID: 26309812; PubMed Central PMCID: PMC4542010.
4. Paschall AV, Yang D, Lu C, Choi JH, Li X, Liu F, Figueroa M, Oberlies NH, Pearce C, Bollag WB, Nayak-Kapoor A, Liu K. H3K9 Trimethylation Silences Fas Expression To Confer Colon Carcinoma Immune Escape and 5-Fluorouracil Chemoresistance. J Immunol. 2015 Aug 15;195(4):1868-82. doi: 10.4049/jimmunol.1402243. Epub 2015 Jul 1. PubMed PMID: 26136424; PubMed Central PMCID: PMC4530033.