Zalypsis

TargetMol
Product Code: TAR-T29202
Supplier: TargetMol
CodeSizePrice
TAR-T29202-5mg5mg£2,456.00
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Quantity:
TAR-T29202-50mg50mg£4,874.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T29202-100mg100mg£6,898.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

1 / 1

Further Information

Bioactivity:
Zalypsis, a transcription factor inhibitor, is used potentially for the treatment of lymphoma, and cervical carcinoma.
CAS:
308359-57-1
Formula:
C37H38F3N3O8
Molecular Weight:
709.719
Purity:
0.98
SMILES:
[H][C@@]12Cc3cc(C)c(OC)c(O)c3[C@@]([H])(N1C)[C@]1([H])Cc3c(OC(C)=O)c(C)c4OCOc4c3[C@H](CNC(=O)C=Cc3cccc(c3)C(F)(F)F)N1[C@H]2O

References

1. Moneo V, Serelde BG, Blanco-Aparicio C, Diaz-Uriarte R, Avil?s P, Santamar?a G, Tercero JC, Cuevas C, Carnero A. Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis. BMC Cancer. 2014 Apr 23;14:281. doi: 10.1186/1471-2407-14-281. PubMed PMID: 24758355; PubMed Central PMCID: PMC4023704. 2. Colado E, Pa?no T, Maiso P, Ocio EM, Chen X, Alvarez-Fern?ndez S, Guti?rrez NC, Mart?n-S?nchez J, Flores-Montero J, San Segundo L, Garayoa M, Fern?ndez-L?zaro D, Vidriales MB, Galmarini CM, Avil?s P, Cuevas C, Pandiella A, San-Miguel JF. Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response. Haematologica. 2011 May;96(5):687-95. doi: 10.3324/haematol.2010.036400. PubMed PMID: 21330323; PubMed Central PMCID: PMC3084915. 3. Romano M, Frapolli R, Zangarini M, Bello E, Porcu L, Galmarini CM, Garc?a-Fern?ndez LF, Cuevas C, Allavena P, Erba E, D'Incalci M. Comparison of in vitro and in vivo biological effects of trabectedin, lurbinectedin (PM01183) and Zalypsis? (PM00104). Int J Cancer. 2013 Nov;133(9):2024-33. doi: 10.1002/ijc.28213. PubMed PMID: 23588839. 4. Leal JF, Garc?a-Hern?ndez V, Moneo V, Domingo A, Bueren-Calabuig JA, Negri A, Gago F, Guill?n-Navarro MJ, Avil?s P, Cuevas C, Garc?a-Fern?ndez LF, Galmarini CM. Molecular pharmacology and antitumor activity of Zalypsis in several human cancer cell lines. Biochem Pharmacol. 2009 Jul 15;78(2):162-70. doi: 10.1016/j.bcp.2009.04.003. PubMed PMID: 19427997.