TargetMol

Apremilast

Product Code:
 
TAR-T2923
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2923-5mg5mg£107.00
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Quantity:
TAR-T2923-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T2923-10mg10mg£121.00
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TAR-T2923-25mg25mg£128.00
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TAR-T2923-50mg50mg£144.00
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Quantity:
TAR-T2923-100mg100mg£149.00
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Quantity:
TAR-T2923-200mg200mg£200.00
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Quantity:
TAR-T2923-500mg500mg£291.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Apremilast (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
CAS:
608141-41-9
Formula:
C22H24N2O7S
Molecular Weight:
460.5
Pathway:
Apoptosis; Metabolism
Purity:
0.9921
SMILES:
CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)N1C(=O)c2cccc(NC(C)=O)c2C1=O
Target:
Apoptosis; TNF; PDE

References

1. Perez-Aso M, et al. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015 Sep 15;17:249. 2. Chen LG, et al. Determination of Apremilast in Rat Plasma by UPLC-MS-MS and Its Application to a Pharmacokinetic Study. J Chromatogr Sci. 2016 Sep;54(8):1336-40.