5-Formylcytosine
| Code | Size | Price |
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| TAR-T29453-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
5-formylcytosine (5FC) is a rare base found in mammalian DNA. It participates in active DNA demethylation, changes DNA double helix structure, and reduces the transcription rate and substrate specificity of RNA polymerase II.
CAS:
4425-59-6
Formula:
C5H5N3O2
Molecular Weight:
139.114
Purity:
0.98
SMILES:
Nc1[nH]c(=O)ncc1C=O
References
1. Wagner M, Steinbacher J, Kraus TF, Michalakis S, Hackner B, Pfaffeneder T, Perera A, M?ller M, Giese A, Kretzschmar HA, Carell T. Age-dependent levels of 5-methyl-, 5-hydroxymethyl-, and 5-formylcytosine in human and mouse brain tissues. Angew Chem Int Ed Engl. 2015 Oct 12;54(42):12511-4. doi: 10.1002/anie.201502722. Epub 2015 Jul 3. PubMed PMID: 26137924; PubMed Central PMCID: PMC4643189.
2. Klungland A, Robertson AB. Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine. Free Radic Biol Med. 2016 Nov 24. pii: S0891-5849(16)31072-3. doi: 10.1016/j.freeradbiomed.2016.11.038. [Epub ahead of print] Review. PubMed PMID: 27890639.
3. Zhu C, Gao Y, Guo H, Xia B, Song J, Wu X, Zeng H, Kee K, Tang F, Yi C. Single-Cell 5-Formylcytosine Landscapes of Mammalian Early Embryos and ESCs at Single-Base Resolution. Cell Stem Cell. 2017 May 4;20(5):720-731.e5. doi: 10.1016/j.stem.2017.02.013. Epub 2017 Mar 23. PubMed PMID: 28343982.
4. Van Haute L, Powell CA, Minczuk M. Dealing with an Unconventional Genetic Code in Mitochondria: The Biogenesis and Pathogenic Defects of the 5-Formylcytosine Modification in Mitochondrial tRNA(Met). Biomolecules. 2017 Mar 2;7(1). pii: E24. doi: 10.3390/biom7010024. Review. PubMed PMID: 28257121; PubMed Central PMCID: PMC5372736.