AKN-028 trifluoroacetate
Code | Size | Price |
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TAR-T29802-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T29802-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T29802-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
AKN-028 trifluoroacetate induces cell cycle arrest, downregulation of Myc associated genes, and dose-dependent reduction of tyrosine kinase activity in acute myeloid leukemia.
CAS:
1175017-91-0
Formula:
C19H15F3N6O2
Molecular Weight:
416.364
Purity:
0.98
SMILES:
OC(=O)C(F)(F)F.Nc1ncc(nc1Nc1ccc2[nH]ccc2c1)-c1ccncc1
References
1. Eriksson A, Kalushkova A, Jarvius M, Hilhorst R, Rickardson L, Kultima HG, de Wijn R, Hovestad L, Frykn?s M, ?berg F, Larsson R, Parrow V, H?glund M. AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and dose dependent reduction of tyrosine kinase activity in acute myeloid leukemia. Biochem Pharmacol. 2014 Jan 15;87(2):284-91. doi: 10.1016/j.bcp.2013.10.022. Epub 2013 Nov 4. PubMed PMID: 24200998.
2. Eriksson A, Hermanson M, Wickstr?m M, Lindhagen E, Ekholm C, Jenmalm Jensen A, L?thgren A, Lehmann F, Larsson R, Parrow V, H?glund M. The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia. Blood Cancer J. 2012 Aug 3;2:e81. doi: 10.1038/bcj.2012.28. PubMed PMID: 22864397; PubMed Central PMCID: PMC3432483.