Akuammicine
| Code | Size | Price |
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| TAR-T29805-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Akuammicine, as an indole alkaloid from Catharanthus roseus, can be used in cancer cell eradication.
CAS:
639-43-0
Formula:
C20H22N2O2
Molecular Weight:
322.408
Purity:
0.98
SMILES:
COC(=O)C1=C2Nc3ccccc3[C@@]22CCN3CC(=C/C)[C@H]1C[C@@H]23
References
1. Tatsis EC, Carqueijeiro I, Dug? de Bernonville T, Franke J, Dang TT, Oudin A, Lanoue A, Lafontaine F, Stavrinides AK, Clastre M, Courdavault V, O'Connor SE. A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate. Nat Commun. 2017 Aug 22;8(1):316. doi: 10.1038/s41467-017-00154-x. PubMed PMID: 28827772; PubMed Central PMCID: PMC5566405.
2. Munagala S, Sirasani G, Kokkonda P, Phadke M, Krynetskaia N, Lu P, Sharom FJ, Chaudhury S, Abdulhameed MD, Tawa G, Wallqvist A, Martinez R, Childers W, Abou-Gharbia M, Krynetskiy E, Andrade RB. Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication. Bioorg Med Chem. 2014 Feb 1;22(3):1148-55. doi: 10.1016/j.bmc.2013.12.022. Epub 2013 Dec 21. PubMed PMID: 24405813.