TargetMol

(E)-Cardamonin

Product Code:
 
TAR-T2994
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2994-10mg10mg£97.00
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TAR-T2994-1mL1 mL * 10 mM (in DMSO)£100.00
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TAR-T2994-25mg25mg£117.00
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TAR-T2994-50mg50mg£134.00
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TAR-T2994-100mg100mg£164.00
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Further Information

Bioactivity:
Cardamomin (also known as cardamonin) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM. It has received growing attention from the scientific community due to the expectations toward its benefits to human health.
CAS:
19309-14-9
Formula:
C16H14O4
Molecular Weight:
270.284
Pathway:
Membrane transporter/Ion channel; Apoptosis
Purity:
0.9984
SMILES:
COc1cc(O)cc(O)c1C(=O)C=Cc1ccccc1
Target:
Apoptosis; TRP/TRPV Channel

References

1. Wang S, et al. Cardamonin, a Novel Antagonist of hTRPA1 Cation Channel, Reveals Therapeutic Mechanism of Pathological Pain. Molecules. 2016 Aug 29;21(9). pii: E1145. 2. Park MK, et al. Novel anti-nociceptive effects of cardamonin via blocking expression of cyclooxygenase-2 andtransglutaminase-2. Pharmacol Biochem Behav. 2014 Mar;118:10-5. 3. He J, Zhou H, Meng J, et al. Cardamonin retards progression of autosomal dominant polycystic kidney disease via inhibiting renal cyst growth and interstitial fibrosis[J]. Pharmacological Research. 2020: 104751. 4. Zhilei Wang, Guang Xu, Yuan Gao, Xiaoyan Zhan, Nan Qin, Shubin Fu, Ruisheng Li et al. Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome [J]. Acta Pharmaceutica Sinica B. 2019 Feb 14.