Ambruticin
| Code | Size | Price |
|---|
| TAR-T29954-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Ambruticin is a biochemical.
CAS:
58857-02-6
Formula:
C28H42O6
Molecular Weight:
474.638
Purity:
0.98
SMILES:
CC[C@H]1O[C@H](CC=C1C)C(C)=C[C@H](C)C=C[C@H]1[C@@H](C)[C@@H]1C=C[C@@H]1O[C@H](CC(O)=O)C[C@H](O)[C@H]1O
References
1. Hemmerling F, Lebe KE, Wunderlich J, Hahn F. An Unusual Fatty Acyl:Adenylate Ligase (FAAL)-Acyl Carrier Protein (ACP) Didomain in Ambruticin Biosynthesis. Chembiochem. 2018 Mar 8. doi: 10.1002/cbic.201800084. [Epub ahead of print] PubMed PMID: 29517170.
2. Ma Y, Yun YK, Wondergem Nee Lukesh J, Sar A, Gone JR, Lindeman S, Donaldson WA. Reactivity of (1-methoxycarbonylpentadienyl)iron(1+) cations with hydride, methyl, and nitrogen nucleophiles. Tetrahedron. 2017 Jul 27;73(30):4493-4500. doi: 10.1016/j.tet.2017.06.026. Epub 2017 Jun 15. PubMed PMID: 29200513; PubMed Central PMCID: PMC5703425.
3. Sung KH, Berkhan G, Hollmann T, Wagner L, Blankenfeldt W, Hahn F. Insights into the Dual Activity of a Bifunctional Dehydratase-Cyclase Domain. Angew Chem Int Ed Engl. 2018 Jan 2;57(1):343-347. doi: 10.1002/anie.201707774. Epub 2017 Dec 6. PubMed PMID: 29084363.
4. Berkhan G, Merten C, Holec C, Hahn F. The Interplay between a Multifunctional Dehydratase Domain and a C-Methyltransferase Effects Olefin Shift in Ambruticin Biosynthesis. Angew Chem Int Ed Engl. 2016 Oct 17;55(43):13589-13592. doi: 10.1002/anie.201607827. Epub 2016 Sep 27. PubMed PMID: 27670141.