Amidantel free base
| Code | Size | Price |
|---|
| TAR-T29979L-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T29979L-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T29979L-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Amidantel free base is a new aminophenylamidine with an interesting anthelminthic spectrum. In rodents the compound is active against nematodes, filariae and cestodes. Of special interest is the high efficacy in dogs against hookworms and large roundworms. Amidantel was well tolerated by all animals tested and did not show teratogenic effects.
CAS:
49745-00-8
Formula:
C13H19N3O2
Molecular Weight:
249.314
Purity:
0.98
SMILES:
COCC(=O)Nc1ccc(cc1)N=C(/C)N(C)C
References
1. Robertson AP, Puttachary S, Buxton SK, Martin RJ. Tribendimidine: mode of action and nAChR subtype selectivity in Ascaris and Oesophagostomum. PLoS Negl Trop Dis. 2015 Feb 13;9(2):e0003495. doi: 10.1371/journal.pntd.0003495. eCollection 2015 Feb. PubMed PMID: 25679515; PubMed Central PMCID: PMC4334517.
2. Duthaler U, Keiser J, Huwyler J. LC-MS/MS method for the determination of two metabolites of tribendimidine, deacylated amidantel and its acetylated metabolite in plasma, blood and dried blood spots. J Pharm Biomed Anal. 2015 Feb;105:163-73. doi: 10.1016/j.jpba.2014.12.006. Epub 2014 Dec 12. PubMed PMID: 25553533.
3. Kulke D, Kr?cken J, Harder A, von Samson-Himmelstjerna G. Efficacy of cyclooctadepsipeptides and aminophenylamidines against larval, immature and mature adult stages of a parasitologically characterized trichurosis model in mice. PLoS Negl Trop Dis. 2014 Feb 20;8(2):e2698. doi: 10.1371/journal.pntd.0002698. eCollection 2014 Feb. PubMed PMID: 24587460; PubMed Central PMCID: PMC3930511.
4. Fontana E, Pignatti A, Ghiglieri A, Battaglia R, Cinato F, Wang C, de Hostos E. Carbon-14 labelled tribendimidine, a broad-spectrum anthelmintic drug. J Labelled Comp Radiopharm. 2013 Jul-Aug;56(9-10):471-4. doi: 10.1002/jlcr.3070. Epub 2013 Jul 9. PubMed PMID: 24285523.