TargetMol

3',?4',?5',?5,?7-?Pentamethoxyflavone

Product Code:
 
TAR-T2A2486
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2A2486-1mg1mg£127.00
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TAR-T2A2486-5mg5mg£209.00
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TAR-T2A2486-1mL1 mL * 10 mM (in DMSO)£226.00
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TAR-T2A2486-10mg10mg£309.00
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TAR-T2A2486-25mg25mg£466.00
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TAR-T2A2486-50mg50mg£647.00
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TAR-T2A2486-100mg100mg£863.00
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Further Information

Bioactivity:
3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adjuvant sensitizer to increase the efficacy of chemotherapeutic drugs by downregulating Nrf2 signaling pathway, it sensitizes Cisplatin-resistant A549 cells to Cisplatin by inhibition of Nrf2 pathway.
CAS:
53350-26-8
Formula:
C20H20O7
Molecular Weight:
372.4
Pathway:
Chromatin/Epigenetic; Apoptosis; Proteases/Proteasome; Neuroscience; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Immunology/Inflammation
Purity:
0.98
SMILES:
COc1cc(OC)c2c(c1)oc(cc2=O)-c1cc(OC)c(OC)c(OC)c1
Target:
BCL; PARP; Caspase; Nrf2; P-gp

References

Cai H, et al. Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone). Cancer Chemother Pharmacol. 2011;67(2):255-263. Cai H, et al. Determination of 3',4',5',5,7-pentamethoxyflavone in the plasma and intestinal mucosa of mice by HPLC with UV detection. Biomed Chromatogr. 2009;23(4):335-339. Hou X, et al. 3',4',5',5,7-pentamethoxyflavone sensitizes Cisplatin-resistant A549 cells to Cisplatin by inhibition of Nrf2 pathway. Mol Cells. 2015;38(5):396-401.