Apratoxin A
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| TAR-T30104-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Apratoxin A is a potent cytotoxin isolated from the marine cyanobacterium Lyngbya majuscula Harvey ex Gomont.
CAS:
350791-64-9
Formula:
C45H69N5O9S
Molecular Weight:
856.13
Purity:
0.98
SMILES:
COc1ccc(C[C@H](NC(=O)C(C)=C[C@H]2CSC(=N2)[C@@H](C)[C@@H](O)C[C@H](C)C[C@H](O)C(C)(C)C)C(=O)N(C)[C@@H](C)C(=O)N(C)[C@H]2[C@@H](C)C(C)OC(=O)[C@@H]3CCCN3C2=O)cc1
References
1. Doi T. Synthesis of the biologically active natural product cyclodepsipeptides apratoxin A and its analogues. Chem Pharm Bull (Tokyo). 2014;62(8):735-43. PubMed PMID: 25087625.
2. Huang KC, Chen Z, Jiang Y, Akare S, Kolber-Simonds D, Condon K, Agoulnik S, Tendyke K, Shen Y, Wu KM, Mathieu S, Choi HW, Zhu X, Shimizu H, Kotake Y, Gerwick WH, Uenaka T, Woodall-Jappe M, Nomoto K. Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61. Mol Cancer Ther. 2016 Jun;15(6):1208-16. doi: 10.1158/1535-7163.MCT-15-0648. Epub 2016 Mar 29. PubMed PMID: 27196783.
3. Thornburg CC, Cowley ES, Sikorska J, Shaala LA, Ishmael JE, Youssef DT, McPhail KL. Apratoxin H and apratoxin A sulfoxide from the Red Sea cyanobacterium Moorea producens. J Nat Prod. 2013 Sep 27;76(9):1781-8. doi: 10.1021/np4004992. Epub 2013 Sep 9. PubMed PMID: 24016099; PubMed Central PMCID: PMC3969888.
4. Masuda Y, Suzuki J, Onda Y, Fujino Y, Yoshida M, Doi T. Total synthesis and conformational analysis of apratoxin C. J Org Chem. 2014 Sep 5;79(17):8000-9. doi: 10.1021/jo501130b. Epub 2014 Aug 18. PubMed PMID: 25093538.