Ascididemin
| Code | Size | Price |
|---|
| TAR-T30152-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Ascididemin can be regarded as a fused phenanthroline with quinoline.
CAS:
114622-04-7
Formula:
C18H9N3O
Molecular Weight:
283.29
Purity:
0.98
SMILES:
O=C1c2cccnc2-c2nccc3c4ccccc4nc1c23
References
1. Yin H, Shan N, Wang S, Yao ZJ. Total synthesis of ascididemin-type alkaloids using alkyne building blocks. J Org Chem. 2014 Oct 17;79(20):9748-53. doi: 10.1021/jo501927e. Epub 2014 Sep 30. PubMed PMID: 25238030.
2. Morvan D. Functional metabolomics uncovers metabolic alterations associated to severe oxidative stress in MCF7 breast cancer cells exposed to ascididemin. Mar Drugs. 2013 Oct 11;11(10):3846-60. doi: 10.3390/md11103846. PubMed PMID: 24152560; PubMed Central PMCID: PMC3826138.
3. Petersen IN, Crestey F, Kristensen JL. Total synthesis of ascididemin via anionic cascade ring closure. Chem Commun (Camb). 2012 Sep 18;48(72):9092-4. doi: 10.1039/c2cc34725c. Epub 2012 Aug 3. PubMed PMID: 22864261.
4. Guittat L, De Cian A, Rosu F, Gabelica V, De Pauw E, Delfourne E, Mergny JL. Ascididemin and meridine stabilise G-quadruplexes and inhibit telomerase in vitro. Biochim Biophys Acta. 2005 Aug 5;1724(3):375-84. PubMed PMID: 15950388.