Austrocortirubin
| Code | Size | Price |
|---|
| TAR-T30214-5mg | 5mg | £1,167.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Austrocortirubin is a DNA damage inducer at the G0/G1, S, and G2 cell cycle stages distinct from other DNA damage agents.
CAS:
150461-82-8
Formula:
C16H16O7
Molecular Weight:
320.297
Purity:
0.98
SMILES:
COc1cc(O)c2C(=O)C3=C(C[C@@](C)(O)C[C@@H]3O)C(=O)c2c1O
References
1. Beattie KD, Ellwood N, Kumar R, Yang X, Healy PC, Choomuenwai V, Quinn RJ, Elliott AG, Huang JX, Chitty JL, Fraser JA, Cooper MA, Davis RA. Antibacterial and antifungal screening of natural products sourced from Australian fungi and characterisation of pestalactams D-F. Phytochemistry. 2016 Apr;124:79-85. doi: 10.1016/j.phytochem.2015.12.014. Epub 2015 Dec 29. PubMed PMID: 26743853.
2. Wang Y, Islam MA, Davis RA, McAlpine SR. The fungal natural product (1S,3S)-austrocortirubin induces DNA damage in HCT116 cells via a mechanism unique from other DNA damaging agents. Bioorg Med Chem Lett. 2015 Jan 15;25(2):249-53. doi: 10.1016/j.bmcl.2014.11.055. Epub 2014 Nov 29. PubMed PMID: 25499433.
3. Choomuenwai V, Andrews KT, Davis RA. Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold. Bioorg Med Chem. 2012 Dec 15;20(24):7167-74. doi: 10.1016/j.bmc.2012.09.052. Epub 2012 Oct 10. PubMed PMID: 23117170.
4. Beattie KD, Rouf R, Gander L, May TW, Ratkowsky D, Donner CD, Gill M, Grice ID, Tiralongo E. Antibacterial metabolites from Australian macrofungi from the genus Cortinarius. Phytochemistry. 2010 Jun;71(8-9):948-55. doi: 10.1016/j.phytochem.2010.03.016. Epub 2010 Apr 12. PubMed PMID: 20392467.