AVE-2865
| Code | Size | Price |
|---|
| TAR-T30218-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
AVE-2865 is a biochemical.
CAS:
648917-13-9
Formula:
C20H17ClF3N3O4
Molecular Weight:
455.82
Purity:
0.98
SMILES:
OC(=O)C1CCN(CC1)c1ccc(F)cc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl
References
1. Kun A, Sepr?nyi G, Varr? A, Papp JG, Pataricza J. Neurogenic contraction induced by the antiarrhythmic compound, AVE 0118, in rat small mesenteric arteries. Basic Clin Pharmacol Toxicol. 2014 Oct;115(4):315-20. doi: 10.1111/bcpt.12225. Epub 2014 Apr 3. Erratum in: Basic Clin Pharmacol Toxicol. 2015 Apr;116(4):384. PubMed PMID: 24629214.
2. Tikhonov DB, Zhorov BS. Homology modeling of Kv1.5 channel block by cationic and electroneutral ligands. Biochim Biophys Acta. 2014 Mar;1838(3):978-87. doi: 10.1016/j.bbamem.2013.11.019. Epub 2013 Dec 5. PubMed PMID: 24316168.
3. Wirth KJ, Steinmeyer K, Ruetten H. Sensitization of upper airway mechanoreceptors as a new pharmacologic principle to treat obstructive sleep apnea: investigations with AVE0118 in anesthetized pigs. Sleep. 2013 May 1;36(5):699-708. doi: 10.5665/sleep.2630. PubMed PMID: 23633752; PubMed Central PMCID: PMC3624824.
4. Hillman D. A new pharmacological treatment to treat obstructive sleep apnea? Sleep. 2013 May 1;36(5):635-6. doi: 10.5665/sleep.2614. PubMed PMID: 23633744; PubMed Central PMCID: PMC3624816.