A 83-01
| Code | Size | Price |
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| TAR-T3031-5mg | 5mg | £113.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T3031-10mg | 10mg | £142.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T3031-50mg | 50mg | £287.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12 nM, 45 nM and 7.5 nM, respectively.
Biological Applications:
There are many small molecules used in reprogramming, which can be categorized into four types: metabolic regulators, epigenetic modifiers, signaling modulators, and aging inhibitors. In this issue, we introduce three commonly used small molecule signaling modulators in reprogramming: 1) A 83-01 and SB-431542 inhibit the activity of TGF-β type I receptors ALK5/4/7 kinases. TGF-β plays a crucial role in stem cell culture. Stem cells possess active paracrine functions and can secrete a large amount of transforming growth factors through exosomes. TGF-β promotes stem cell proliferation, aiding in the maintenance of their numbers. A 83-01 and SB-431542, as TGF-β inhibitors, are commonly used to inhibit the differentiation of iPSCs and maintain the self-renewal of cells in vitro. A 83-01 is generally used for the culture of gastrointestinal, hepatic, prostatic, and mammary organoids, while SB-431542 is typically used for the culture of lung and inner ear organoids. 2) SB 202190 is a potent p38 MAPK kinase inhibitor that can induce human embryonic stem cells to differentiate into cardiac muscle cells and promote the self-renewal of neural stem cells. It can be used for the culture of gastrointestinal, mammary, and prostatic organoids.
CAS:
909910-43-6
Formula:
C25H19N5S
Long Description:
A 83-01, also known as ALK5 Inhibitor IV, is an inhibitor of TGF-β type I receptors ALK5, ALK4, and ALK7 (IC50 = 12/45/7.5 nM). A 83-01 promotes the reprogramming of mouse fibroblasts into induced pluripotent stem cells (iPSCs). It can also be used for organoid culture.
Molecular Weight:
421.52
Pathway:
Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
Purity:
0.9876
Research Area:
Organoid
SMILES:
Cc1cccc(n1)-c1nn(cc1-c1ccnc2ccccc12)C(=S)Nc1ccccc1
Target:
ALK; TGF-beta/Smad
References
1. Yamamura S, et al. The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer. Int J Cancer. 2012 Jan 1;130(1):20-8.
2. Kawano K, Maitani Y. Tumor permeability of nanocarriers observed by dynamic contrast-enhanced magnetic resonance imaging. Yakugaku Zasshi. 2010 Dec;130(12):1679-85.
3. Taniguchi, Y., Kawano, K., Minowa, T., Sugino, T., Shimojo, Y., & Maitani, Y. (2010). Enhanced antitumor efficacy of folate-linked liposomal doxorubicin with TGF-? type I receptor inhibitor.?Cancer Science,?101(10), 2207-2213. doi: 10.1111/j.1349-7006.2010.01646.x
4. Wei-jian L I, Zhen-yu W, Tian-jie Y, et al. The study of immortalized hepatocyte-derived liver progenitor-like cells used in bioartificial liver therapy[J]. Chinese Hepatolgy. 24(8): 871.
5. Gong-Bo Fu, Wei-Jian Huang, Min Zeng, Xu Zhou, Hong-Ping Wu, Chang-Cheng Liu, Han Wu, Jun Weng, Hong-Dan Zhang, Yong-Chao Cai, Charles Ashton, Min Ding, Dan Tang, Bao-Hua Zhang, Yi Gao, Wei-Feng Yu, Bo Zhai, Zhi-Ying He, Hong-Yang Wang, and He-Xin Yan . Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens [J]. Cell Research. 2019 Jan;29(1):8-22.