BMS 180448
| Code | Size | Price |
|---|
| TAR-T30487-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T30487-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T30487-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
BMS 180448 is a prototype mitochondrial ATP-sensitive K+ (Mitok (ATP)) channel opener with cardioprotective and vasodilating properties.
CAS:
144264-47-1
Formula:
C20H18ClN5O2
Molecular Weight:
395.85
Purity:
0.98
SMILES:
CC1(C)Oc2ccc(cc2[C@H](N=C(NC#N)Nc2ccc(Cl)cc2)[C@H]1O)C#N
References
1. Lee JH, Jung IS, Lee SH, Yang MK, Hwang JH, Lee HD, Cho YS, Song MJ, Yi KY, Yoo SE, Kwon SH, Kim B, Lee CS, Shin HS. Cardioprotective effects of BMS-180448, a prototype mitoK(ATP) channel opener, and the role of salvage kinases, in the rat model of global ischemia and reperfusion heart injury. Arch Pharm Res. 2007 May;30(5):634-40. PubMed PMID: 17615684.
2. Park YS, Yoo SE, Shin HS, Jin YR, Yun YP. Pharmacological characterization of vasorelaxant effects of BMS-180448, a novel cardioselective ATP-sensitive potassium channel opener, in rat aorta. J Pharmacol Sci. 2003 Jul;92(3):218-27. PubMed PMID: 12890887.
3. Weselcouch EO, Gomoll AW. Selectivity of BMS-180448 on myocardial versus brain blood flow in dogs and ferrets. J Cardiovasc Pharmacol. 1997 Jul;30(1):61-8. PubMed PMID: 9268222.
4. Gomoll AW, Roth RA, Swillo RE, Baird AJ, Sargent CS, Behling RW, Malone HJ, Grover GJ. Effect of timing of treatment of the glyburide-reversible cardioprotective activity of BMS-180448. J Pharmacol Exp Ther. 1997 Apr;281(1):24-33. PubMed PMID: 9103476.