CB 3703
| Code | Size | Price |
|---|
| TAR-T30761-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T30761-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T30761-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
CB 3703 is an inhibitor of dihydrofolate reductase and thymidylate synthase.
CAS:
32093-09-7
Formula:
C22H24N6O5
Molecular Weight:
452.471
Purity:
0.98
SMILES:
Cc1c(CNc2ccc(cc2)C(=O)N[C@H](CCC(O)=O)C(O)=O)ccc2nc(N)nc(N)c12
References
1. Sikora F, Grzelakowska-Sztabert B. Quinazoline CB 3717 and CB 3703 inhibition of folate retention and metabolism in Ehrlich ascites carcinoma cells and some organs of the host-mouse. Cancer Lett. 1984 Jul;23(3):289-95. PubMed PMID: 6744253.
2. Sikora E, Grzelakowska-Sztabert B. A quinazoline antifolate as inhibitor of folate metabolism in mouse L-cells. Acta Biochim Pol. 1983;30(2):193-201. PubMed PMID: 6868908.
3. Grzelakowska-Sztabert B, Bali?ska M, Chmurzy?ska W, Manteuffel-Cymborowska M, Zieli?ska ZM. Target and non-target metabolic effects of aminofolates and of a 5-methylquinazoline antifolate in mouse cells. Biochem Pharmacol. 1980 Oct 15;29(20):2741-9. PubMed PMID: 7437080.
4. Calvert AH, Jones TR, Dady PJ, Grzelakowska-Sztabert B, Paine RM, Taylor GA, Harrap KR. Quinazoline antifolates with dual biochemical loci of action. Biochemical and biological studies directed towards overcoming methotrexate resistance. Eur J Cancer. 1980 May;16(5):713-22. PubMed PMID: 7389797.