CC-3052
| Code | Size | Price |
|---|
| TAR-T30774-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T30774-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T30774-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
CC-3052 is a water-soluble, highly stable thalidomide analogue that is an effective inhibitor of HIV-1 expression and activation-induced TNF-α production. CC-3052 also inhibited PHA-induced and rTNF-α induced TNF-α transcription in PBMC, as well as TNF-α transcription due to the adhesion of purified monocytes to tissue culture flask.
CAS:
216884-02-5
Formula:
C20H21NO5
Molecular Weight:
355.39
Purity:
0.98
SMILES:
COC(=O)[C@@H](CN1Cc2ccccc2C1=O)c1ccc(OC)c(OC)c1
References
1. Lee YK, Chung SK. The inhibitory effect of thalidomide analogue on corneal neovascularization in rabbits. Cornea. 2013 Aug;32(8):1142-8. doi: 10.1097/ICO.0b013e318292a79d. PubMed PMID: 23739149.
2. Subbian S, Tsenova L, O'Brien P, Yang G, Koo MS, Peixoto B, Fallows D, Dartois V, Muller G, Kaplan G. Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs. PLoS Pathog. 2011 Sep;7(9):e1002262. doi: 10.1371/journal.ppat.1002262. Epub 2011 Sep 15. PubMed PMID: 21949656; PubMed Central PMCID: PMC3174258.
3. Subbian S, Tsenova L, O'Brien P, Yang G, Koo MS, Peixoto B, Fallows D, Zeldis JB, Muller G, Kaplan G. Phosphodiesterase-4 inhibition combined with isoniazid treatment of rabbits with pulmonary tuberculosis reduces macrophage activation and lung pathology. Am J Pathol. 2011 Jul;179(1):289-301. doi: 10.1016/j.ajpath.2011.03.039. Epub 2011 May 7. PubMed PMID: 21703411; PubMed Central PMCID: PMC3123788.
4. Koo MS, Manca C, Yang G, O'Brien P, Sung N, Tsenova L, Subbian S, Fallows D, Muller G, Ehrt S, Kaplan G. Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice. PLoS One. 2011 Feb 25;6(2):e17091. doi: 10.1371/journal.pone.0017091. PubMed PMID: 21364878; PubMed Central PMCID: PMC3045423.