Cgp 12388
| Code | Size | Price |
|---|
| TAR-T30811-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
CGP 12388 is a radioactive ligand derived from a β-adrenergic receptor antagonist and is used for cardiac PET imaging due to its high hydrophilicity and affinity for β-adrenergic receptors.
CAS:
108929-47-1
Formula:
C13H17N3O3
Molecular Weight:
263.297
Purity:
0.98
SMILES:
CC(C)NC[C@@H](O)COc1cccc2=NC(=O)N=c12
References
1. van Waarde A, Maas B, Doze P, Slart RH, Frijlink HW, Vaalburg W, Elsinga PH. Positron emission tomography studies of human airways using an inhaled beta-adrenoceptor antagonist, S-11C-CGP 12388. Chest. 2005 Oct;128(4):3020-7. PubMed PMID: 16236982.
2. Doze P, Elsinga PH, van Waarde A, Pieterman RM, Pruim J, Vaalburg W, Willemsen AT. Quantification of beta-adrenoceptor density in the human heart with (S)-[11C]CGP 12388 and a tracer kinetic model. Eur J Nucl Med Mol Imaging. 2002 Mar;29(3):295-304. PubMed PMID: 12002702.
3. Elsinga PH, van Waarde A, Jaeggi KA, Schreiber G, Heldoorn M, Vaalburg W. Synthesis and evaluation of (S)-4-(3-(2'-[11C]isopropylamino)-2-hydroxypropoxy) -2H-benzimidazol -2-one ((S)-[11C]CGP 12388) and (S)-4-(3-((1'-[18F]-fluoroisopropyl)amino)-2-hydroxypropoxy) -2H- benzimidazol-2-one ((S)-[18F]fluoro-CGP 12388) for visualization of beta-adrenoceptors with positron emission tomography. J Med Chem. 1997 Nov 7;40(23):3829-35. PubMed PMID: 9371248.