CP-472555
| Code | Size | Price |
|---|
| TAR-T31060-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
CP-472555 is a selective nonsteroidal glucocorticoid receptor antagonist with anti-GR and anti-obesity activity in animal models.
CAS:
305821-96-9
Formula:
C31H32N2O2
Molecular Weight:
464.609
Purity:
0.98
SMILES:
CC#C[C@@]1(O)CC[C@]2(Cc3ccccc3)[C@H](CCc3cc(ccc23)C(=O)NCc2cccnc2)C1
References
1. Briski KP, Kale AY, Vavaiya KV. Impact of recurring intermediate insulin-induced hypoglycemia on hypothalamic paraventricular corticotropin-releasing hormone, oxytocin, vasopressin and glucokinase gene profiles: role of type II glucocorticoid receptors. Exp Brain Res. 2009 Jun;195(4):499-507. doi: 10.1007/s00221-009-1787-4. Epub 2009 May 6. PubMed PMID: 19418044.
2. Kale AY, Paranjape SA, Briski KP. Type II glucocorticoid receptor involvement in habituated activation of lateral hypothalamic area orexin-A-immunopositive neurons during recurring insulin-induced hypoglycemia. Neurosci Res. 2006 Nov;56(3):309-13. Epub 2006 Sep 25. PubMed PMID: 16997409.
3. Kale AY, Vavaiya KV, Briski KP. Effects of acute and chronic insulin-induced hypoglycemia on type II glucocorticoid receptor (GR) gene expression in characterized CNS metabolic loci. Brain Res Bull. 2006 Jul 31;70(3):240-4. Epub 2006 Jun 6. PubMed PMID: 16861109.
4. Kale AY, Paranjape SA, Briski KP. Site-specific habituation of insulin-induced hypoglycemic induction of fos immunoreactivity in glucocorticoid receptor: immunopositive neurons in the male rat brain. Exp Brain Res. 2007 Jan;176(2):260-6. PubMed PMID: 16850320.