DB-766
| Code | Size | Price |
|---|
| TAR-T31215-5mg | 5mg | £1,091.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T31215-50mg | 50mg | £2,143.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T31215-100mg | 100mg | £2,801.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
DB-766 is a potential chemotherapeutic candidate for Chagas' disease treatment. DB-766 exhibits strong trypanocidal activity and excellent selectivity for bloodstream trypomastigotes and intracellular amastigotes (Y strain), giving IC(50)s of 60 and 25 nM, respectively. The trypanocidal efficacy of DB766, suggesting that this AIA may represent a new lead compound candidate to Chagas.
CAS:
423165-22-4
Formula:
C34H34N6O3
Molecular Weight:
574.685
Purity:
0.98
SMILES:
CC(C)Oc1cc(NC(=N)c2ccccn2)ccc1-c1ccc(o1)-c1ccc(NC(=N)c2ccccn2)cc1OC(C)C
References
1. Pandharkar T, Zhu X, Mathur R, Jiang J, Schmittgen TD, Shaha C, Werbovetz KA. Studies on the antileishmanial mechanism of action of the arylimidamide DB766: azole interactions and role of CYP5122A1. Antimicrob Agents Chemother. 2014 Aug;58(8):4682-9. doi: 10.1128/AAC.02405-14. Epub 2014 Jun 2. PubMed PMID: 24890590; PubMed Central PMCID: PMC4135980.
2. Srivastava A, Sweat JM, Azizan A, Vesely B, Kyle DE. Real-time PCR to quantify Leishmania donovani in hamsters. J Parasitol. 2013 Feb;99(1):145-50. doi: 10.1645/GE-3221.1. Epub 2012 Aug 27. PubMed PMID: 22924923.
3. Reid CS, Farahat AA, Zhu X, Pandharkar T, Boykin DW, Werbovetz KA. Antileishmanial bis-arylimidamides: DB766 analogs modified in the linker region and bis-arylimidamide structure-activity relationships. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6806-10. doi: 10.1016/j.bmcl.2012.06.037. Epub 2012 Jun 16. PubMed PMID: 22765899.
4. Zhu X, Liu Q, Yang S, Parman T, Green CE, Mirsalis JC, de Nazar? Correia Soeiro M, Mello de Souza E, da Silva CF, da Gama Jaen Batista D, Stephens CE, Banerjee M, Farahat AA, Munde M, Wilson WD, Boykin DW, Wang MZ, Werbovetz KA. Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies. Antimicrob Agents Chemother. 2012 Jul;56(7):3690-9. doi: 10.1128/AAC.06404-11. Epub 2012 Apr 16. PubMed PMID: 22508306; PubMed Central PMCID: PMC3393454.