Deacetylgedunin
| Code | Size | Price |
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| TAR-T31243-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Deacetylgedunin is a limonoid that is the 7-deacetyl derivative of gedunin. It has been isolated from Azadirachta indica.
CAS:
10314-90-6
Formula:
C26H32O6
Molecular Weight:
440.536
Purity:
0.98
SMILES:
CC1(C)[C@@H]2C[C@@H](O)[C@]3(C)[C@H](CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@@]345)c3ccoc3)[C@@]2(C)C=CC1=O
References
1. Chen JY, Zhu GY, Su XH, Wang R, Liu J, Liao K, Ren R, Li T, Liu L. 7-deacetylgedunin suppresses inflammatory responses through activation of Keap1/Nrf2/HO-1 signaling. Oncotarget. 2017 Jul 5;8(33):55051-55063. doi: 10.18632/oncotarget.19017. eCollection 2017 Aug 15. PubMed PMID: 28903401; PubMed Central PMCID: PMC5589640.
2. Akihisa T, Nishimoto Y, Ogihara E, Matsumoto M, Zhang J, Abe M. Nitric Oxide Production-Inhibitory Activity of Limonoids from Azadirachta indica and Melia azedarach. Chem Biodivers. 2017 Jun;14(6). doi: 10.1002/cbdv.201600468. Epub 2017 May 23. PubMed PMID: 28145090.
3. Sarigaputi C, Sangpech N, Palaga T, Pudhom K. Suppression of inducible nitric oxide synthase pathway by 7-deacetylgedunin, a limonoid from Xylocarpus sp. Planta Med. 2015 Mar;81(4):312-9. doi: 10.1055/s-0034-1396308. Epub 2015 Feb 25. PubMed PMID: 25714725.
4. Pereira TB, Rocha E Silva LF, Amorim RC, Melo MR, Zacardi de Souza RC, Eberlin MN, Lima ES, Vasconcellos MC, Pohlit AM. In vitro and in vivo anti-malarial activity of limonoids isolated from the residual seed biomass from Carapa guianensis (andiroba) oil production. Malar J. 2014 Aug 13;13:317. doi: 10.1186/1475-2875-13-317. PubMed PMID: 25124944; PubMed Central PMCID: PMC4138406.