Difenamizole
| Code | Size | Price |
|---|
| TAR-T31454-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Difenamizole is a nonsteroidal anti-inflammatory drug (NSAID), which is a pyrazolinone analgesic drug-related to Analgin. It has monoaminergic properties, including inhibition of monoamine oxidase, an increase of pargyline-induced striatal dopamine levels, inhibition of K+ -induced striatal dopamine release, and inhibition of dopamine reuptake.
CAS:
20170-20-1
Formula:
C20H22N4O
Molecular Weight:
334.423
Purity:
0.98
SMILES:
CC(N(C)C)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1
References
1. Kameyama T, Nabeshima T, Yoshida N, Yamaguchi K. Neurochemical studies of an analgesic, 1,3-diphenyl-5-(2-dimethylaminopropionamide)-pyrazole [difenamizole]. Res Commun Chem Pathol Pharmacol. 1981 Jan;31(1):31-53. PubMed PMID: 6454942.
2. Kameyama T, Ukai M, Nabeshima T. Inhibitory effect of difenamizole on morphine-induced straub tail reaction with special reference to monoaminergic agents. Chem Pharm Bull (Tokyo). 1978 Nov;26(11):3265-70. PubMed PMID: 729114.
3. Nabeshima T, Yamaguchi K, Kameyama T. Effects of difenamizole on content of catecholamines and metabolites in mouse brain. Jpn J Pharmacol. 1978 Aug;28(4):642-6. PubMed PMID: 732046.
4. Kameyama T, Nabeshima T. Effects of 1,3-diphenyl-5-(2-dimethylaminopropionamide)-pyrazole[difenamizole] on a conditioned avoidance response. Neuropharmacology. 1978 Apr-May;17(4-5):249-56. PubMed PMID: 652137.