FMHM
| Code | Size | Price |
|---|
| TAR-T31834-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T31834-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T31834-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
FMHM is a TRAF6 scavenging agent via ubiquitination-dependent mode.
CAS:
1426543-96-5
Formula:
C11H12O5
Molecular Weight:
224.212
Purity:
0.98
SMILES:
OCCC(=C)C(=O)OCc1ccc(C=O)o1
References
1. Zeng KW, Liao LX, Lv HN, Song FJ, Yu Q, Dong X, Li J, Jiang Y, Tu PF. Natural small molecule FMHM inhibits lipopolysaccharide-induced inflammatory response by promoting TRAF6 degradation via K48-linked polyubiquitination. Sci Rep. 2015 Oct 1;5:14715. doi: 10.1038/srep14715. PubMed PMID: 26423026; PubMed Central PMCID: PMC4589686.
2. Zeng KW, Li J, Dong X, Wang YH, Ma ZZ, Jiang Y, Jin HW, Tu PF. Anti-neuroinflammatory efficacy of the aldose reductase inhibitor FMHM via phospholipase C/protein kinase C-dependent NF-?B and MAPK pathways. Toxicol Appl Pharmacol. 2013 Nov 15;273(1):159-71. doi: 10.1016/j.taap.2013.08.028. Epub 2013 Sep 7. PubMed PMID: 24021941.
3. Ventura C, Cantoni S, Bianchi F, Lionetti V, Cavallini C, Scarlata I, Foroni L, Maioli M, Bonsi L, Alviano F, Fossati V, Bagnara GP, Pasquinelli G, Recchia FA, Perbellini A. Hyaluronan mixed esters of butyric and retinoic Acid drive cardiac and endothelial fate in term placenta human mesenchymal stem cells and enhance cardiac repair in infarcted rat hearts. J Biol Chem. 2007 May 11;282(19):14243-52. Epub 2007 Mar 15. PubMed PMID: 17363374.
4. Westerberg VS, Geiger JD. Inhibitors of histidine decarboxylase decrease basal gastric acid secretion in the rat. Pharmacol Biochem Behav. 1987 Nov;28(3):419-22. PubMed PMID: 3685079.