GNE-3476
Code | Size | Price |
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TAR-T31979-5mg | 5mg | £1,171.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T31979-50mg | 50mg | £2,303.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T31979-100mg | 100mg | £3,042.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
GNE-3476 is an NMDA receptor PAM. Ge-3476 has different degrees of activity on different receptors.GNE-3476 has relatively low efficacy on GluN2A, some activity as an AMPAR PAM, and weak activity at GluN2B-containing receptors.
CAS:
951499-16-4
Formula:
C18H22N4OS
Molecular Weight:
342.46
Purity:
0.98
SMILES:
CCCCc1nn2c(nc(CN(CC)c3ccccc3)cc2=O)s1
References
1. Volgraf, M.; Sellers, B. D.; Jiang, Y.; Wu, G.; Ly, C. Q.; Villemure, E.; Pastor, R. M.; Yuen, P. W.; Lu, A.; Luo, X.; Liu, M.; Zhang, S.; Sun, L.; Fu, Y.; Lupardus, P. J.; Wallweber, H. J.; Liederer, B. M.; Deshmukh, G.; Plise, E.; Tay, S.; Reynen, P.; Herrington, J.; Gustafson, A.; Liu, Y.; Dirksen, A.; Dietz, M. G.; Liu, Y.; Wang, T. M.; Hanson, J. E.; Hackos, D.; Scearce-Levie, K.; Schwarz, J. B. Discovery of GluN2A-selective NMDA receptor positive allosteric modulators (PAMs): Tuning deactivation kinetics via structure-based design. J. Med. Chem. 2016, 59, 2760?2779.