TargetMol

GNE-3476

Product Code:
 
TAR-T31979
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T31979-5mg5mg£1,171.00
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Quantity:
TAR-T31979-50mg50mg£2,303.00
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Quantity:
TAR-T31979-100mg100mg£3,042.00
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This product comes from: United States.
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Further Information

Bioactivity:
GNE-3476 is an NMDA receptor PAM. Ge-3476 has different degrees of activity on different receptors.GNE-3476 has relatively low efficacy on GluN2A, some activity as an AMPAR PAM, and weak activity at GluN2B-containing receptors.
CAS:
951499-16-4
Formula:
C18H22N4OS
Molecular Weight:
342.46
Purity:
0.98
SMILES:
CCCCc1nn2c(nc(CN(CC)c3ccccc3)cc2=O)s1

References

1. Volgraf, M.; Sellers, B. D.; Jiang, Y.; Wu, G.; Ly, C. Q.; Villemure, E.; Pastor, R. M.; Yuen, P. W.; Lu, A.; Luo, X.; Liu, M.; Zhang, S.; Sun, L.; Fu, Y.; Lupardus, P. J.; Wallweber, H. J.; Liederer, B. M.; Deshmukh, G.; Plise, E.; Tay, S.; Reynen, P.; Herrington, J.; Gustafson, A.; Liu, Y.; Dirksen, A.; Dietz, M. G.; Liu, Y.; Wang, T. M.; Hanson, J. E.; Hackos, D.; Scearce-Levie, K.; Schwarz, J. B. Discovery of GluN2A-selective NMDA receptor positive allosteric modulators (PAMs): Tuning deactivation kinetics via structure-based design. J. Med. Chem. 2016, 59, 2760?2779.