GNF-1331
Code | Size | Price |
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TAR-T31983-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T31983-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T31983-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
GNF-1331 is a potent, selective, and orally bioavailable porcupine inhibitor (IC50 = 12 nM). Blocking abnormal Wnt signaling is an attractive treatment for a variety of cancers.
CAS:
603101-22-0
Formula:
C20H20N6O2S2
Molecular Weight:
440.54
Purity:
0.98
SMILES:
CCCn1c(SCC(=O)Nc2nc3ccc(OC)cc3s2)nnc1-c1ccncc1
References
1. Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors Dai Cheng, Jun Liu, Dong Han, Guobao Zhang, Wenqi Gao, Mindy H. Hsieh, Nicholas Ng, Shailaja Kasibhatla, Celin Tompkins, Jie Li, Auzon Steffy, Fangxian Sun, Chun Li, H. Martin Seidel, Jennifer L. Harris, and Shifeng Pan Publication Date (Web): May 10, 2016 (Letter) doi: 10.1021/acsmedchemlett.6b00038