GYKI-16638 HCl
| Code | Size | Price |
|---|
| TAR-T32030-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T32030-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T32030-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
GYKI-16638 is a novel antiarrhythmic agent that demonstrates combined class IB and class III antiarrhythmic properties in human ventricular muscles, similar to the electrophysiological findings after chronic amiodarone treatment. In addition, GYKI 16638 has an in vivo antiarrhythmic effect comparable to that of D-sotalol.
CAS:
307556-59-8
Formula:
C21H31ClN2O5S
Molecular Weight:
459
Purity:
0.98
SMILES:
Cl.COc1cccc(OC)c1OCC(C)N(C)CCc1ccc(NS(C)(=O)=O)cc1
References
1. M?tyus P, Varga I, Rettegi T, Simay A, K?llay N, K?rolyh?zy L, Kocsis A, Varr? A, P?nzes I, Papp JG. Novel antiarrhythmic compounds with combined class IB and class III mode of action. Curr Med Chem. 2004 Jan;11(1):61-9. Review. PubMed PMID: 14754426.
2. Opincariu M, Varr? A, Iost N, Vir?g L, H?la O, Szolnoki J, Sz?csi J, Bog?ts G, Szenohradszky P, M?tyus P, Papp JG. The cellular electrophysiologic effect of a new amiodarone like antiarrhythmic drug GYKI 16638 in undiseased human ventricular muscle: comparison with sotalol and mexiletine. Curr Med Chem. 2002 Jan;9(1):41-6. PubMed PMID: 11860346.
3. Baczk? I, El-Reyani NE, Farkas A, Vir?g L, Iost N, Lepr?n I, M?tyus P, Varr? A, Papp JG. Antiarrhythmic and electrophysiological effects of GYKI-16638, a novel N-(phenoxyalkyl)-N-phenylalkylamine, in rabbits. Eur J Pharmacol. 2000 Sep 15;404(1-2):181-90. PubMed PMID: 10980278.