GYKI-53784
| Code | Size | Price |
|---|
| TAR-T32035-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T32035-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T32035-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
GYKI-53784 (LY 303070) is an effective selective AMPA receptor antagonist.
CAS:
161832-71-9
Formula:
C19H20N4O3
Molecular Weight:
352.394
Purity:
0.98
SMILES:
CNC(=O)N1N=C(c2ccc(N)cc2)c2cc3OCOc3cc2C[C@H]1C
References
1. Ruel J, Guitton MJ, Puell JL. Negative allosteric modulation of AMPA-preferring receptors by the selective isomer GYKI 53784 (LY303070), a specific non-competitive AMPA antagonist. CNS Drug Rev. 2002 Fall;8(3):235-54. Review. PubMed PMID: 12353057.
2. Ruel J, Bobbin RP, Vidal D, Pujol R, Puel JL. The selective AMPA receptor antagonist GYKI 53784 blocks action potential generation and excitotoxicity in the guinea pig cochlea. Neuropharmacology. 2000 Aug 23;39(11):1959-73. PubMed PMID: 10963740.
3. Kapus G, B?di I, Pataki A, Gueritaud J, Sz?kely JI, Tarnawa I. Differential modulation of the GYKI 53784-induced inhibition of AMPA currents by various AMPA-positive modulators in cerebellar Purkinje cells. Eur J Pharmacol. 2000 May 26;397(1):43-7. PubMed PMID: 10844097.
4. Ruiz A, Durand J. Modulation of kainate-induced responses by pentobarbitone and GYKI-53784 in rat abducens motoneurons in vivo. Brain Res. 1999 Feb 13;818(2):421-30. PubMed PMID: 10082828.