Heme arginate
| Code | Size | Price |
|---|
| TAR-T32054-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Heme arginine (or heme arginine) is a compound of heme and arginine used to treat acute porphyria by reducing the excessive production of δ-aminolevulinic acid, which causes acute symptoms during the onset of acute porphyria.
CAS:
100438-92-4
Formula:
C40H46FeN8O6
Molecular Weight:
790.703
Purity:
0.98
SMILES:
N[C@@H](CCCNC(N)=N)C(O)=O.CC1=C(CCC(O)=O)C2=[N+]3C1=Cc1c(C=C)c(C)c4C=C5C(C=C)=C(C)C6=[N+]5[Fe--]3(n14)n1c(=C6)c(C)c(CCC(O)=O)c1=C2
References
1. Edmunds MC, Czopek A, Wigmore SJ, Kluth DC. Paradoxical effects of heme arginate on survival of myocutaneous flaps. Am J Physiol Regul Integr Comp Physiol. 2014 Jan 1;306(1):R10-22. doi: 10.1152/ajpregu.00240.2013. Epub 2013 Oct 2. PubMed PMID: 24089372; PubMed Central PMCID: PMC3921308.
2. Choudhary AK, Rennie J, Cairns C, Borthwick G, Hughes J, Morton NM, Kluth D, Conway BR. Administration of heme arginate ameliorates murine type 2 diabetes independently of heme oxygenase activity. PLoS One. 2013 Oct 30;8(10):e78209. doi: 10.1371/journal.pone.0078209. eCollection 2013 Oct 30. PubMed PMID: 24205160; PubMed Central PMCID: PMC3813508.
3. Melenovsk? P, Kopeck? J, Krijt J, Hn?zda A, Rakov? K, Jano??k M, Wilcken B, Ko?ich V. Chaperone therapy for homocystinuria: the rescue of CBS mutations by heme arginate. J Inherit Metab Dis. 2015 Mar;38(2):287-94. doi: 10.1007/s10545-014-9781-9. Epub 2014 Oct 21. PubMed PMID: 25331909.
4. Andreas M, Schmid AI, Doberer D, Schewzow K, Weisshaar S, Heinze G, Bilban M, Moser E, Wolzt M. Heme arginate improves reperfusion patterns after ischemia: a randomized, placebo-controlled trial in healthy male subjects. J Cardiovasc Magn Reson. 2012 Aug 2;14:55. doi: 10.1186/1532-429X-14-55. PubMed PMID: 22857721; PubMed Central PMCID: PMC3438022.