Henagliflozin
| Code | Size | Price |
|---|
| TAR-T32058-5mg | 5mg | £1,332.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T32058-50mg | 50mg | £2,625.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T32058-100mg | 100mg | £3,524.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Henagliflozin (SHR3824) is an effective, oral, and selective SGLT2 inhibitor that effectively inhibits human SGLT2 in vitro, but has very weak inhibitory effects on human SGLT1.
CAS:
1623804-44-3
Formula:
C22H24ClFO7
Molecular Weight:
454.88
Purity:
0.98
SMILES:
CCOc1ccc(Cc2cc(ccc2Cl)[C@@]23OC[C@@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1F
References
1. Yong X, Wen A, Liu X, Liu H, Liu YP, Li N, Hu T, Chen Y, Wang M, Wang L, Dai X, Huang J, Li J, Shen H. Pharmacokinetics and Pharmacodynamics of Henagliflozin, a Sodium Glucose Co-Transporter 2 Inhibitor, in Chinese Patients with Type 2 Diabetes Mellitus. Clin Drug Investig. 2016 Mar;36(3):195-202. doi: 10.1007/s40261-015-0366-7. PubMed PMID: 26692004.
2. Wang L, Wu C, Shen L, Liu H, Chen Y, Liu F, Wang Y, Yang J. Evaluation of drug-drug interaction between henagliflozin, a novel sodium-glucose co-transporter 2 inhibitor, and metformin in healthy Chinese males. Xenobiotica. 2016 Aug;46(8):703-8. doi: 10.3109/00498254.2015.1113576. Epub 2015 Nov 26. PubMed PMID: 26608671.
3. Yan PK, Zhang LN, Feng Y, Qu H, Qin L, Zhang LS, Leng Y. SHR3824, a novel selective inhibitor of renal sodium glucose cotransporter 2, exhibits antidiabetic efficacy in rodent models. Acta Pharmacol Sin. 2014 May;35(5):613-24. doi: 10.1038/aps.2013.196. PubMed PMID: 24786232; PubMed Central PMCID: PMC4814034.