Homofolic acid
| Code | Size | Price |
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| TAR-T32100-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Homofolic acid is a folic acid analog.
CAS:
3566-25-4
Formula:
C20H21N7O6
Molecular Weight:
455.431
Purity:
0.98
SMILES:
Nc1nc(=O)c2nc(CCNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2[nH]1
References
1. Bazzano LA, Reynolds K, Holder KN, He J. Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. JAMA. 2006 Dec 13;296(22):2720-6. Erratum in: JAMA. 2007 Mar 7;297(9):952. PubMed PMID: 17164458.
2. Henderson GB, Strauss BP. Growth inhibition by homofolate in tumor cells utilizing a high-affinity folate binding protein as a means for folate internalization. Biochem Pharmacol. 1990 Jun 15;39(12):2019-25. PubMed PMID: 2353941.
3. Thorndike J, Gaumont Y, Kisliuk RL, Sirotnak FM, Murthy BR, Nair MG, Piper JR. Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts. Cancer Res. 1989 Jan 1;49(1):158-63. PubMed PMID: 2521177.
4. Slieker LJ, Benkovic SJ. Inhibition of HKSV28 cell growth by 5,11-methenyl-tetrahydrohomofolate. Mol Pharmacol. 1984 Mar;25(2):294-302. PubMed PMID: 6700575.