Hypusine HCl
| Code | Size | Price |
|---|
| TAR-T32126L-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Hypusine HCl is an unusual amino acid found in all eukaryotes and in some archaea, but not in bacteria. The only known protein containing hypusine is eukaryotic translation initiation factor 5A (eIF5A) and a similar protein found in archaebacteria.
CAS:
82310-93-8
Formula:
C10H25Cl2N3O3
Molecular Weight:
306.23
Purity:
0.98
SMILES:
Cl.Cl.NCC[C@@H](O)CNCCCC[C@H](N)C(O)=O
References
1. Dever TE, Gutierrez E, Shin BS. The hypusine-containing translation factor eIF5A. Crit Rev Biochem Mol Biol. 2014 Sep-Oct;49(5):413-25. doi: 10.3109/10409238.2014.939608. Epub 2014 Jul 17. Review. PubMed PMID: 25029904; PubMed Central PMCID: PMC4183722.
2. P?llmann N, Braig M, Sievert H, Preukschas M, Hermans-Borgmeyer I, Schweizer M, Nagel CH, Neumann M, Wild P, Haralambieva E, Hagel C, Bokemeyer C, Hauber J, Balabanov S. Biological Relevance and Therapeutic Potential of the Hypusine Modification System. J Biol Chem. 2015 Jul 24;290(30):18343-60. doi: 10.1074/jbc.M115.664490. Epub 2015 Jun 2. PubMed PMID: 26037925; PubMed Central PMCID: PMC4513096.
3. Zhai Q, He M, Song A, Deshayes K, Dixit VM, Carter PJ. Structural Analysis and Optimization of Context-Independent Anti-Hypusine Antibodies. J Mol Biol. 2016 Feb 13;428(3):603-617. doi: 10.1016/j.jmb.2016.01.006. Epub 2016 Jan 14. PubMed PMID: 26778617.
4. Fujimura K, Wright T, Strnadel J, Kaushal S, Metildi C, Lowy AM, Bouvet M, Kelber JA, Klemke RL. A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer. Cancer Res. 2014 Nov 15;74(22):6671-81. doi: 10.1158/0008-5472.CAN-14-1031. Epub 2014 Sep 26. PubMed PMID: 25261239; PubMed Central PMCID: PMC4233190.