Iproplatin
| Code | Size | Price |
|---|
| TAR-T32189-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Iproplatin is a synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death. Although less prone to glutathione inactivation compared to cisplatin, resistance to this agent has been observed in vitro due to repair of platination damage by tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
CAS:
62928-11-4
Formula:
C6H20Cl2N2O2Pt
Molecular Weight:
418.22
Purity:
0.98
SMILES:
CC(C)[NH2+][Pt--](O)(O)(Cl)(Cl)[NH2+]C(C)C
References
1. Volckova E, Weaver E, Bose RN. Insight into the reactive form of the anticancer agent iproplatin. Eur J Med Chem. 2008 May;43(5):1081-4. Epub 2007 Jul 10. PubMed PMID: 17707553.
2. Pawinski A, Crowther D, Keizer HJ, Voûte PA, Somers R, van Glabbeke M, Lentz MA, van Oosterom AT. The EORTC Phase II study of iproplatin in advanced osteogenic sarcoma. Eur J Cancer. 1999 Jan;35(1):163-4. PubMed PMID: 10211107.
3. Zhong W, Zhang Q, Yan Y, Yue S, Zhang B, Tang W. Interaction of sodium chloroplatinate and iproplatin with metallothionein in vivo. J Inorg Biochem. 1997 May 15;66(3):159-64. PubMed PMID: 9130391.
4. Pendyala L, Perez R, Weinstein A, Zdanowicz J, Creaven PJ. Effect of glutathione depletion on the cytotoxicity of cisplatin and iproplatin in a human melanoma cell line. Cancer Chemother Pharmacol. 1997;40(1):38-44. PubMed PMID: 9137527.