IWP-051
| Code | Size | Price |
|---|
| TAR-T32242-5mg | 5mg | £1,171.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T32242-50mg | 50mg | £2,303.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T32242-100mg | 100mg | £3,042.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
IWP-051 is a potent, orally active sGC stimulator (EC50 = 290nM). IWP-051 showed >99% plasma protein binding, high metabolic stability, high permeability, and no efflux in a Caco-2 model of intestinal absorption. IWP-051 achieves good alignment of potency, stability, selectivity, and pharmacodynamic effects while maintaining favorable pharmacokinetic properties with once-daily dosing potential in humans.
CAS:
1354041-91-0
Formula:
C17H11F2N5O2
Molecular Weight:
355.305
Purity:
0.98
SMILES:
Fc1ccccc1Cn1nc(cc1-c1ccon1)-c1ncc(F)c(=O)[nH]1
References
1. Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans Takashi Nakai, Nicholas R. Perl, Timothy C. Barden, Andrew Carvalho, Angelika Fretzen, Peter Germano, G-Yoon J. Im, Hong Jin, Charles Kim, Thomas W.-H. Lee, Kimberly Long, Joel Moore, Jason M. Rohde, Renee Sarno, Chrissie Segal, Erik O. Solberg, Jenny Tobin, Daniel P. Zimmer, and Mark G. Currie Publication Date (Web): February 24, 2016 (Letter) DOI: 10.1021/acsmedchemlett.5b00479
2. BMC Pharmacol Toxicol. 2015; 16(Suppl 1): PMCID: PMC4565103 Discovery of IWP-051, a novel orally bioavailable soluble guanylate cyclase stimulator with sustained and dose-dependent hemodynamic effects Takashi Nakai,1 Nicholas R Perl,1 Rajesh R Iyengar,corresponding author1 Ara Mermerian,et al.