KMH-233
Code | Size | Price |
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TAR-T32404-5mg | 5mg | £389.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T32404-50mg | 50mg | £1,669.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T32404-100mg | 100mg | £2,464.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
KMH-233 is a potent selective LAT1 inhibitor 1 that inhibits the uptake of LAT1 substrate, L-leucine, and cell growth. Even at low concentrations (25 μM), it significantly enhanced the efficacy of betastatin and cisplatin.
CAS:
1941174-13-5
Formula:
C32H25N7O5
Molecular Weight:
587.596
Purity:
0.98
SMILES:
CNC(=O)COc1ccc(cc1)-c1c(C#N)c(NC(=O)c2cccc(C[C@H](N)C(O)=O)c2)n2c3ccccc3nc2c1C#N
References
1. A Selective and Slowly Reversible Inhibitor of l-Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells Kristiina M. Huttunen, Mikko Gynther, Johanna Huttunen, Elena Puris, Julie A. Spicer, and William A. Denny Publication Date (Web): June 2, 2016 (Article) doi: 10.1021/acs.jmedchem.6b00190