KP1019
| Code | Size | Price |
|---|
| TAR-T32417-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
KP1019 is now discontinued.
CAS:
124875-20-3
Formula:
C21H19Cl4N6Ru
Molecular Weight:
598.29
Purity:
0.98
SMILES:
c1[nH+][nH]c2ccccc12.Cl[Ru--](Cl)(Cl)(Cl)([n+]1cc2ccccc2[nH]1)[n+]1cc2ccccc2[nH]1
References
1. Jones MR, Mu C, Wang MC, Webb MI, Walsby CJ, Storr T. Modulation of the A? peptide aggregation pathway by KP1019 limits A?-associated neurotoxicity. Metallomics. 2015 Jan 24;7(1):129-35. doi: 10.1039/c4mt00252k. Epub 2014 Nov 12. PubMed PMID: 25387614.
2. Kuhn PS, Büchel GE, Jovanovi? KK, Filipovi? L, Radulovi? S, Rapta P, Arion VB. Osmium(III) analogues of KP1019: electrochemical and chemical synthesis, spectroscopic characterization, X-ray crystallography, hydrolytic stability, and antiproliferative activity. Inorg Chem. 2014 Oct 20;53(20):11130-9. doi: 10.1021/ic501710k. Epub 2014 Oct 7. PubMed PMID: 25290960.
3. Sadafi FZ, Massai L, Bartolommei G, Moncelli MR, Messori L, Tadini-Buoninsegni F. Anticancer ruthenium(III) complex KP1019 interferes with ATP-dependent Ca2+ translocation by sarco-endoplasmic reticulum Ca2+-ATPase (SERCA). ChemMedChem. 2014 Aug;9(8):1660-4. doi: 10.1002/cmdc.201402128. Epub 2014 Jun 11. PubMed PMID: 24920093.
4. Singh V, Azad GK, Reddy M A, Baranwal S, Tomar RS. Anti-cancer drug KP1019 induces Hog1 phosphorylation and protein ubiquitylation in Saccharomyces cerevisiae. Eur J Pharmacol. 2014 Aug 5;736:77-85. doi: 10.1016/j.ejphar.2014.04.032. Epub 2014 May 2. PubMed PMID: 24797784.