KS 501
Code | Size | Price |
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TAR-T32421-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
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Further Information
Bioactivity:
KS 501 interferes with calmodulin activation and is isolated from Sporothrix sp. KAC-1985.
CAS:
120634-86-8
Formula:
C33H48O10
Molecular Weight:
604.737
Purity:
0.98
SMILES:
CCCCCCCc1cc(O)cc(OC(=O)c2c(CCCCCCC)cc(O)cc2O[C@@H]2O[C@@H]([C@H](O)CO)[C@H](O)[C@H]2O)c1
References
1. Yasuzawa T, Saitoh Y, Sano H. Structures of KS-501 and KS-502, the new inhibitors of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase. J Antibiot (Tokyo). 1990 Apr;43(4):336-43. PubMed PMID: 2161817.
2. Hait WN, Gesmonde J, Cheng E. Effects of KS-501, KS-502 and their enantiomers on calmodulin-sensitive enzyme activity and cellular proliferation. Biochem Pharmacol. 1995 Jun 29;50(1):69-74. PubMed PMID: 7605347.
3. Nakanishi S, Ando K, Kawamoto I, Kase H. KS-501 and KS-502, new inhibitors of Ca2+ and calmodulin-dependent cyclic-nucleotide phosphodiesterase from Sporothrix sp. J Antibiot (Tokyo). 1989 Jul;42(7):1049-55. PubMed PMID: 2546910.
4. Bunyapaiboonsri T, Yoiprommarat S, Khonsanit A, Komwijit S. Phenolic glycosides from the filamentous fungus Acremonium sp. BCC 14080. J Nat Prod. 2008 May;71(5):891-4. doi: 10.1021/np070689m. Epub 2008 Mar 26. PubMed PMID: 18363379.