KW 2149
| Code | Size | Price |
|---|
| TAR-T32429-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
KW 2149 is a compound derived from mitomycin C.
CAS:
118359-59-4
Formula:
C24H34N6O8S2
Molecular Weight:
598.69
Purity:
0.98
SMILES:
[H][C@]12CN3C4=C([C@@H](COC(N)=O)[C@@]3(OC)[C@@]1([H])N2)C(=O)C(NCCSSCCN[C@@H](CCC(N)=O)C(O)=O)=C(C)C4=O
References
1. Lee SH, Kohn H. 7-N,7'-N'-(1",2"-Dithianyl-3",6"-dimethylenyl)bismitomycin C: synthesis and nucleophilic activation of a dimeric mitomycin. Org Biomol Chem. 2005 Feb 7;3(3):471-82. Epub 2005 Jan 6. PubMed PMID: 15678185.
2. Lee SH, Kohn H. Cyclic disulfide C8 iminoporfiromycin: nucleophilic activation of a porfiromycin. J Am Chem Soc. 2004 Apr 7;126(13):4281-92. PubMed PMID: 15053618.
3. van Acker FA, van Acker SA, Haenen GR, Bast A, van der Vijgh WJ. In vitro screening of antitumour agents for cardiotoxicity by means of isolated mouse left atria. Anticancer Res. 2000 Nov-Dec;20(6B):4483-7. PubMed PMID: 11205292.
4. Takaba K, Furumoto H, Ikegami J, Suzuki K, Takahashi J, Hara T, Ishii A. Inhibitory effects of subcutaneous dexamethasone treatment on rat pulmonary toxicity of KW-2149, a new mitomycin C analogue. Arch Toxicol. 2000 Apr;74(2):106-11. PubMed PMID: 10839478.