L 685818
| Code | Size | Price |
|---|
| TAR-T32465-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
L 685818 is the C18-hydroxy, C21-ethyl of FK-506 analog.
CAS:
143839-74-1
Formula:
C43H69NO13
Molecular Weight:
808.019
Purity:
0.98
SMILES:
[H][C@]12O[C@](O)([C@H](C)C[C@@H]1OC)C(=O)C(=O)N1CCCC[C@@]1([H])C(=O)O[C@@H]([C@H](C)[C@@H](O)CC(=O)[C@H](CC)C=C(C)[C@@H](O)[C@H](C)C[C@@H]2OC)C(C)=C[C@@H]1CCC(O)C(C1)OC
References
1. Onyewu C, Blankenship JR, Del Poeta M, Heitman J. Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei. Antimicrob Agents Chemother. 2003 Mar;47(3):956-64. PubMed PMID: 12604527; PubMed Central PMCID: PMC149324.
2. Kontoyiannis DP, Lewis RE, Osherov N, Albert ND, May GS. Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species. J Antimicrob Chemother. 2003 Feb;51(2):313-6. PubMed PMID: 12562696.
3. Oz HS, Hughes WT, Thomas EK, McClain CJ. Effects of immunomodulators on acute Trypanosoma Cruzi infection in mice. Med Sci Monit. 2002 Jun;8(6):BR208-11. PubMed PMID: 12070425.
4. Guo X, Dawson VL, Dawson TM. Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons. Eur J Neurosci. 2001 May;13(9):1683-93. PubMed PMID: 11359520.