LAI-1
| Code | Size | Price |
|---|
| TAR-T32537-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T32537-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T32537-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
LAI-1 is a regulator of bacterial signaling, modulating gene regulation and cellular responses of eukaryotic cells (amoebae or macrophages) and a variety of processes including pathogen-host cell interactions.
CAS:
1046789-93-8
Formula:
C15H30O2
Molecular Weight:
242.403
Purity:
0.98
SMILES:
CCCCCCCCCCCC(=O)C(O)CC
References
1. Guedes IA, Freitas RH, Cordeiro NM, do Nascimento TS, Valerio TS, Fernandes PD, Dardenne LE, Fraga CA. LASSBio-1829 Hydrochloride: Development of a New Orally Active N-Acylhydrazone IKK2 Inhibitor with Anti-inflammatory Properties. ChemMedChem. 2016 Jan 19;11(2):234-44. doi: 10.1002/cmdc.201500266. Epub 2015 Aug 25. PubMed PMID: 26306006. 1: Personnic N, Striednig B, Hilbi H. Legionella quorum sensing and its role in pathogen-host interactions. Curr Opin Microbiol. 2018 Feb;41:29-35. doi: 10.1016/j.mib.2017.11.010. Epub 2017 Nov 27. Review. PubMed PMID: 29190490.
2. Hochstrasser R, Hilbi H. Intra-Species and Inter-Kingdom Signaling of Legionella pneumophila. Front Microbiol. 2017 Feb 3;8:79. doi: 10.3389/fmicb.2017.00079. eCollection 2017. Review. PubMed PMID: 28217110; PubMed Central PMCID: PMC5289986.
3. Schell U, Simon S, Hilbi H. Inflammasome Recognition and Regulation of the Legionella Flagellum. Curr Top Microbiol Immunol. 2016;397:161-81. doi: 10.1007/978-3-319-41171-2_8. Review. PubMed PMID: 27460809.
4. Simon S, Schell U, Heuer N, Hager D, Albers MF, Matthias J, Fahrnbauer F, Trauner D, Eichinger L, Hedberg C, Hilbi H. Inter-kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway. PLoS Pathog. 2015 Dec 3;11(12):e1005307. doi: 10.1371/journal.ppat.1005307. eCollection 2015 Dec. PubMed PMID: 26633832; PubMed Central PMCID: PMC4669118.