TargetMol

Lamellarin D

Product Code:
 
TAR-T32545
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T32545-5mg5mg£850.00
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TAR-T32545-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T32545-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Lamellarin D, for example, displays strong cytotoxic activity against tumor cell lines, and is a potent topoisomerase I inhibitor.
CAS:
97614-65-8
Formula:
C28H21NO8
Molecular Weight:
499.475
Purity:
0.98
SMILES:
COc1cc(ccc1O)-c1c2c(n3ccc4cc(O)c(OC)cc4c13)c(=O)oc1cc(O)c(OC)cc21

References

1. Lade DM, Pawar AB, Mainkar PS, Chandrasekhar S. Total Synthesis of Lamellarin D Trimethyl Ether, Lamellarin D, and Lamellarin H. J Org Chem. 2017 May 5;82(9):4998-5004. doi: 10.1021/acs.joc.7b00636. Epub 2017 Apr 24. PubMed PMID: 28421766. 2. Colligs V, Hansen SP, Imbri D, Seo EJ, Kadioglu O, Efferth T, Opatz T. Synthesis and biological evaluation of a D-ring-contracted analogue of lamellarin D. Bioorg Med Chem. 2017 Feb 9. pii: S0968-0896(16)31109-9. doi: 10.1016/j.bmc.2017.02.005. [Epub ahead of print] PubMed PMID: 28233677. 3. Dahmane N, Gadelle D, Delmas S, Criscuolo A, Eberhard S, Desnoues N, Collin S, Zhang H, Pommier Y, Forterre P, Sezonov G. topIb, a phylogenetic hallmark gene of Thaumarchaeota encodes a functional eukaryote-like topoisomerase IB. Nucleic Acids Res. 2016 Apr 7;44(6):2795-805. doi: 10.1093/nar/gkw097. Epub 2016 Feb 22. PubMed PMID: 26908651; PubMed Central PMCID: PMC4824112. 4. Manjappa KB, Syu JR, Yang DY. Visible-Light-Promoted and Yb(OTf)3-Catalyzed Constructions of Coumarin-Pyrrole-(Iso)quinoline-Fused Pentacycles: Synthesis of Lamellarin Core, Lamellarin D Trimethyl Ether, and Lamellarin H. Org Lett. 2016 Jan 15;18(2):332-5. doi: 10.1021/acs.orglett.5b03524. Epub 2016 Jan 7. PubMed PMID: 26741300.