Latrunculins A
| Code | Size | Price |
|---|
| TAR-T32588-5mg | 5mg | £3,099.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T32588-50mg | 50mg | £6,159.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T32588-100mg | 100mg | £8,825.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Latrunculins A is a novel marine toxin, disrupts microfilament organization in cultured cells.
CAS:
122876-48-6
Formula:
C22H31NO6S
Molecular Weight:
437.55
Purity:
0.98
SMILES:
[H][C@]12CCC(C)=C/C(=O)O[C@]3([H])C[C@@]([H])(CCC(C)C=C/[C@]1([H])O2)O[C@@](O)(C3)[C@H]1CSC(=O)N1
References
1. Helal MA, Khalifa S, Ahmed S. Differential binding of latrunculins to G-actin: a molecular dynamics study. J Chem Inf Model. 2013 Sep 23;53(9):2369-75. doi: 10.1021/ci400317j. Epub 2013 Aug 29. PubMed PMID: 23988111.
2. Kudrimoti S, Ahmed SA, Daga PR, Wahba AE, Khalifa SI, Doerksen RJ, Hamann MT. Semisynthetic latrunculin B analogs: studies of actin docking support a proposed mechanism for latrunculin bioactivity. Bioorg Med Chem. 2009 Nov 1;17(21):7517-22. doi: 10.1016/j.bmc.2009.09.012. Epub 2009 Sep 16. PubMed PMID: 19800245; PubMed Central PMCID: PMC2782694.
3. Johnson S, Rahmani R, Drew DR, Williams MJ, Wilkinson M, Tan YH, Huang JX, Tonkin CJ, Beeson JG, Baum J, Smith BJ, Baell JB. Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion. J Med Chem. 2016 Dec 22;59(24):10994-11005. doi: 10.1021/acs.jmedchem.6b01109. Epub 2016 Dec 2. PubMed PMID: 28002959.
4. Khalifa S, Ahmed S, Mesbah M, Youssef D, Hamann M. Quantitative determination of latrunculins A and B in the Red Sea sponge Negombata magnifica by high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Feb 17;832(1):47-51. Epub 2006 Jan 18. PubMed PMID: 16431167.