Leurosidine N'b-oxide
| Code | Size | Price |
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| TAR-T32685-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Leurosidine N'b-oxide is a catharanthus alkaloid extracted from Madagascan periwinkle Catharanthus roseus.
CAS:
80374-74-9
Formula:
C46H58N4O10
Molecular Weight:
826.988
Purity:
0.98
SMILES:
CC[C@]1(O)C[C@@H]2CN(=O)(C1)CCc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@H]1[C@@]22CCN3CC=C[C@@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@@]1(O)C(=O)OC
References
1. Mukhopadhyay S, Cordell GA. Catharanthus alkaloids. XXXV. Isolation of leurosidine N'b-oxide from Catharanthus roseus. J Nat Prod. 1981 Sep-Oct;44(5):611-3. PubMed PMID: 7320741.
2. Kuehne ME, Qin Y, Huot AE, Bane SL. The syntheses of 16a'-homo-leurosidine and 16a'-homo-vinblastine. Generation of atropisomers. J Org Chem. 2001 Aug 10;66(16):5317-28. PubMed PMID: 11485450.
3. Ishikawa H, Colby DA, Seto S, Va P, Tam A, Kakei H, Rayl TJ, Hwang I, Boger DL. Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues. J Am Chem Soc. 2009 Apr 8;131(13):4904-16. doi: 10.1021/ja809842b. PubMed PMID: 19292450; PubMed Central PMCID: PMC2727944.
4. Ishikawa H, Colby DA, Boger DL. Direct coupling of catharanthine and vindoline to provide vinblastine: total synthesis of (+)- and ent-(-)-vinblastine. J Am Chem Soc. 2008 Jan 16;130(2):420-1. PubMed PMID: 18081297; PubMed Central PMCID: PMC2570212.