Lexaptepid pegol
| Code | Size | Price |
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| TAR-T32723-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Lexaptepid pegol is a L-oligoribonucleotide known as a Spiegelmer.
CAS:
1390631-57-8
Formula:
C18H37N2O10P
Molecular Weight:
472.472
Purity:
0.98
SMILES:
COCCOCCN(CC(=O)NCCCCCCOP(O)(O)=O)C(=O)COCCOC
References
1. Boyce M, Warrington S, Cortezi B, Z?llner S, Vaul?on S, Swinkels DW, Summo L, Schwoebel F, Riecke K. Safety, pharmacokinetics and pharmacodynamics of the anti-hepcidin Spiegelmer lexaptepid pegol in healthy subjects. Br J Pharmacol. 2016 May;173(10):1580-8. doi: 10.1111/bph.13433. Epub 2016 Apr 8. PubMed PMID: 26773325; PubMed Central PMCID: PMC4842915.
2. Vater A, Klussmann S. Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer(?) therapeutics. Drug Discov Today. 2015 Jan;20(1):147-55. doi: 10.1016/j.drudis.2014.09.004. Epub 2014 Sep 16. Review. PubMed PMID: 25236655.
3. van Eijk LT, John AS, Schwoebel F, Summo L, Vaul?on S, Z?llner S, Laarakkers CM, Kox M, van der Hoeven JG, Swinkels DW, Riecke K, Pickkers P. Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans. Blood. 2014 Oct 23;124(17):2643-6. doi: 10.1182/blood-2014-03-559484. Epub 2014 Aug 27. PubMed PMID: 25163699; PubMed Central PMCID: PMC4208279.
4. Steinbicker AU. A novel treatment of anemia of inflammation. Blood. 2014 Oct 23;124(17):2618-9. doi: 10.1182/blood-2014-09-599282. PubMed PMID: 25342662.