Liga 20
| Code | Size | Price |
|---|
| TAR-T32749-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Liga 20 is a semisynthetic GM1 ganglioside with N-dichloroacetylsphingosine that protecting neurons in culture against glutamate toxicity.
CAS:
126586-85-4
Formula:
C57H97Cl2N3O31
Molecular Weight:
1391.29
Purity:
0.98
SMILES:
CCCCCCCCCCCCCC=C[C@H](O)[C@@H](CO[C@@H]1O[C@H](CO)[C@H](O[C@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O[C@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@@H]4O)[C@@H]3NC(C)=O)[C@H](O[C@@]3(C[C@@H](O)[C@@H](NC(C)=O)[C@H](O3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H]2O)[C@H](O)[C@@H]1O)NC(=O)C(Cl)Cl
References
1. Schneider JS, DiStefano L. LIGA 20 increases striatal dopamine levels in aged MPTP-treated mice refractory to GM1 ganglioside treatment. Neuroreport. 1993 Nov 18;5(2):103-4. PubMed PMID: 8110995.
2. Wu G, Lu ZH, Wang J, Wang Y, Xie X, Meyenhofer MF, Ledeen RW. Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1. J Neurosci. 2005 Nov 23;25(47):11014-22. PubMed PMID: 16306414.
3. Wu G, Lu ZH, Xie X, Li L, Ledeen RW. Mutant NG108-15 cells (NG-CR72) deficient in GM1 synthase respond aberrantly to axonogenic stimuli and are vulnerable to calcium-induced apoptosis: they are rescued with LIGA-20. J Neurochem. 2001 Feb;76(3):690-702. PubMed PMID: 11158239.
4. Hadaczek P, Wu G, Sharma N, Ciesielska A, Bankiewicz K, Davidow AL, Lu ZH, Forsayeth J, Ledeen RW. GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model. Exp Neurol. 2015 Jan;263:177-89. doi: 10.1016/j.expneurol.2014.10.010. Epub 2014 Oct 23. PubMed PMID: 25448159.