LY 295427
| Code | Size | Price |
|---|
| TAR-T33002-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
LY 295427 is a bioactive chemical.
CAS:
152755-31-2
Formula:
C30H52O
Molecular Weight:
428.745
Purity:
0.98
SMILES:
[H][C@@]12CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])[C@H](CC=C)[C@H](O)CC[C@]12C
References
1. Bielska AA, Olsen BN, Gale SE, Mydock-McGrane L, Krishnan K, Baker NA, Schlesinger PH, Covey DF, Ory DS. Side-chain oxysterols modulate cholesterol accessibility through membrane remodeling. Biochemistry. 2014 May 13;53(18):3042-51. doi: 10.1021/bi5000096. Epub 2014 May 1. PubMed PMID: 24758724; PubMed Central PMCID: PMC4020583.
2. Bielska AA, Ory DS, Covey DF. Synthesis of the enantiomer of the oxysterol-antagonist LY295427. Steroids. 2011 Sep-Oct;76(10-11):986-90. doi: 10.1016/j.steroids.2011.03.008. Epub 2011 Apr 4. PubMed PMID: 21470559; PubMed Central PMCID: PMC3139699.
3. Nunomura S, Endo K, Makishima M, Ra C. Oxysterol represses high-affinity IgE receptor-stimulated mast cell activation in Liver X receptor-dependent and -independent manners. FEBS Lett. 2010 Mar 19;584(6):1143-8. doi: 10.1016/j.febslet.2010.02.006. Epub 2010 Feb 9. PubMed PMID: 20138879.
4. Borthwick F, Taylor JM, Bartholomew C, Graham A. Differential regulation of the STARD1 subfamily of START lipid trafficking proteins in human macrophages. FEBS Lett. 2009 Apr 2;583(7):1147-53. doi: 10.1016/j.febslet.2009.02.042. Epub 2009 Mar 10. PubMed PMID: 19272380.