ML277

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TargetMol
Product Code: TAR-T3303
Supplier: TargetMol
CodeSizePrice
TAR-T3303-1mg1mg£98.00
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TAR-T3303-5mg5mg£128.00
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TAR-T3303-1mL1 mL * 10 mM (in DMSO)£144.00
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TAR-T3303-10mg10mg£177.00
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TAR-T3303-25mg25mg£267.00
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TAR-T3303-50mg50mg£434.00
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TAR-T3303-100mg100mg£606.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
ML277 was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).
CAS:
1401242-74-7
Formula:
C23H25N3O4S2
Molecular Weight:
471.6
Pathway:
Membrane transporter/Ion channel
Purity:
0.9997
SMILES:
O=C([C@@H]1N(S(=O)(C2=CC=C(C)C=C2)=O)CCCC1)NC3=NC(C4=CC=C(OC)C=C4)=CS3
Target:
Potassium Channel

References

1. Mattmann ME, Yu H, Lin Z, et al. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012;22(18):5936-5941. doi:10.1016/j.bmcl.2012.07.060 1. Wulff H, et al. Nat Rev Drug Discov. 2009 Dec;8(12):982-1001. 2. Robbins J, et al. Pharmacol Ther. 2001 Apr;90(1):1-19. 3. Mattmann ME, et al. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5936-41. 4. Yu H, et al. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8732-7.