Manoyl oxide
| Code | Size | Price |
|---|
| TAR-T33214-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Manoyl oxide is a proposed intermediate in the biosynthesis of forskolin and other medically important labdane-type terpenoids.
CAS:
596-84-9
Formula:
C20H34O
Molecular Weight:
290.491
Purity:
0.98
SMILES:
[H][C@@]12CC[C@@]3(C)O[C@](C)(CC[C@]3([H])[C@@]1(C)CCCC2(C)C)C=C
References
Englund E, Andersen-Ranberg J, Miao R, Hamberger B, Lindberg P. Metabolic Engineering of Synechocystis sp. PCC 6803 for Production of the Plant Diterpenoid Manoyl Oxide. ACS Synth Biol. 2015 Dec 18;4(12):1270-8. doi: 10.1021/acssynbio.5b00070. Epub 2015 Jul 13. PubMed PMID: 26133196; PubMed Central PMCID: PMC4685428.
Nielsen MT, Ranberg JA, Christensen U, Christensen HB, Harrison SJ, Olsen CE, Hamberger B, M?ller BL, N?rholm MH. Microbial Synthesis of the Forskolin Precursor Manoyl Oxide in an Enantiomerically Pure Form. Appl Environ Microbiol. 2014 Dec;80(23):7258-65. doi: 10.1128/AEM.02301-14. Epub 2014 Sep 19. PubMed PMID: 25239892; PubMed Central PMCID: PMC4249197.
Pateraki I, Andersen-Ranberg J, Hamberger B, Heskes AM, Martens HJ, Zerbe P, Bach SS, M?ller BL, Bohlmann J, Hamberger B. Manoyl oxide (13R), the biosynthetic precursor of forskolin, is synthesized in specialized root cork cells in Coleus forskohlii. Plant Physiol. 2014 Mar;164(3):1222-36. doi: 10.1104/pp.113.228429. Epub 2014 Jan 30. PubMed PMID: 24481136; PubMed Central PMCID: PMC3938615.
Ignea C, Ioannou E, Georgantea P, Trikka FA, Athanasakoglou A, Loupassaki S, Roussis V, Makris AM, Kampranis SC. Production of the forskolin precursor 11?-hydroxy-manoyl oxide in yeast using surrogate enzymatic activities. Microb Cell Fact. 2016 Feb 26;15:46. doi: 10.1186/s12934-016-0440-8. PubMed PMID: 26920948; PubMed Central PMCID: PMC4769550.